Here is a list of 71 plants and three mushrooms, 61 of them drawn from the 78 listed in “Food Use of Wild Plants by Cherokee Indians.” I included only those that I know to be common in Western North Carolina today. I added more, marked in bold, that I believe are likely to have been used. There are surely many, many more, not to mention medicinals like ginseng as well as dozens of animals including deer, bear, crawdads, grubs, grasshoppers, and definitely yellow jackets and hornets.
Another potential resource might be “Contemporary Usage of Native Plant Foods by the Eastern Cherokees.” Local ethnobotanist Marc Williams, has a list of over 300 wild edibles in our area; he wrote a thesis on it. Here is my list of the 125 most common. Two other people who would know a lot are Doug Elliott and Ila Hatter. The person who might know the most about traditional Cherokee use is David Cozzo.
burdock (since about 1650; fresh root)
chickweed (arrived from Europe probably by 1700)
grape: fox, possum, muscadine
hen of the woods
Japanese knotweed (since 1800)
queen of the meadow
raspberry, black raspberry, thimbleberry
violet- purple, white, and yellow